CS | en

Vyhledávání

Celý intranet Aktuální oblast


Důležité odkazy

dulezite-biocev.pngdulezite-avcr.pngdulezite-ov.pngdulezite-tvt.png

Vědecká pracoviště

Open position at the Centre of Molecular Structure

 

Specialist in biological X-ray techniques, especially small-angle X-ray scattering (SAXS) and single crystal X-ray diffraction (plus crystallization), full-time

 

The Centre of Molecular Structure (CMS), part of CIISB (the Czech Infrastructure for Integrative Structural Biology) and one of the European network ERIC-Instruct sites, is operated by the Institute of Biotechnology CAS v. v. i. (BIOCEV), Vestec, central Bohemia, Czech Republic). The CMS is a technology platform providing access to scientific instrumentation and service to researchers, mostly working in “life sciences”.  Details of the scientific equipment and services provided at the CMS can be consulted on this link.

 

We are looking for a specialist in X-ray techniques. The focus of the position is to provide excellent service in maintaining and operating a newly acquired state-of-the-art SAXS line and partially also the X-ray diffraction and crystallisation platform. User support providing training, assistance or sometimes full service (depending on the particular case) is also expected.

The successful candidate will also have the opportunity to collaborate in exciting research projects involving X-rays (both diffraction and scattering) in IBT research groups focused on structural biology. For such additional duties (that will represent up to 50% of the time), practical knowledge of protein and nucleic acid purification and crystallisation is a plus. Participation to data collection trips at synchrotron radiation beam lines is expected.

 

The applicants (preferably having Ph.D. level experience) must have practical experience with bio-SAXS and have a strong interest in providing training and assistance to users and students.

 

The position offered is for an initial period of three years, with the possibility of renewal.

 

Applications (in electronic format, Word document or pdf files preferred) including a cover letter, curriculum vitae, and the names and addresses of three referees must be sent to the main office of the Institute of Biotechnology:

 

Institute of Biotechnology CAS, v. v. i.

Prumyslova 595

252 50 Vestec

Czech Republic

Phone: +420 325 873 700

E-mail: btu-office@ibt.cas.cz

 

Any questions regarding this position can be directed to
Dr Frederic Vellieu
x, frederic.vellieux@ibt.cas.cz

or Dr Jan Dohnalek, dohnalek@ibt.cas.cz

 

Application deadline: 15 December 2017

 

Expected starting date: within the period January – March 2018

                                                                                                                

Laboratoř inženýrství vazebných proteinů hledá

 

motivované Bc. studenty

 

pro práci v biochemicky orientované laboratoři s možností vypracování bakalářské práce v rámci jednoho ze dvou řešených projektů:

  • Immunomodulatory ligands targeted to IL-23/Th17 pro-inflammatory axis as novel tools for development of topical drugs for treatment of psoriasis
  • Construction of recombinant mimotopes for induction of neutralizing antibodies against HIV-1 gp120 glycoprotein using high-affinity binders approach

 

Pro studenta bude v případě zájmu k dispozici částečný pracovní úvazek.

Informace o laboratoři zde.

V případě zájmu kontaktujte RNDr. Petra Malého, CSc. (email: petr.maly@ibt.cas.cz, tel.: 325 873 763, mobil: 731 648 966).

                                                                                                                

Do našeho týmu hledáme zkušeného laboratorního pracovníka na plný úvazek pro servisní laboratoř GeneCore Biotechnologického ústavu AV ČR, v. v. i. v BIOCEVu, která je předním evropským pracovištěm nabízející qPCR a NGS služby.

 

laboratorní pracovník na plný úvazek

 

Náplň práce:

The laboratory worker will work on client’s projects in molecular analysis mainly with real-time PCR and next generation sequencing technologies. The work encompasses all aspects of workflow from sampling, extraction, quality control, molecular analysis, and data analysis. The laboratory worker also contributes as instructor in hands-on training courses in molecular analyses. The laboratory worker is expected to work independently on projects delegated by the Gene Core manager. The GeneCore facility primarily serves researchers at the BIOCEV campus, but also other researcher in Czech Republic and occasional also international customers. The GeneCore collaborates close with TATAA Biocenter (www.tataa.com).

 

Požadavky:

  • Vysokoškolské vzdělání příslušného směru s odbornou praxí
  • Zájem o technologie a metody pro molekulární analýzy
  • Schopnost pracovat jak samostatně tak i ve skupině
  • Spolehlivost a flexibilita
  • Chuť do práce a odhodlání učit se novým věcem
  • Znalost anglického jazyka slovem i písmem

 

Nabízíme:

  • Pracovní poměr na dobu určitou s možností prodloužení (možné i na zkrácený úvazek)
  • Odpovídající platové ohodnocení
  • Atraktivní pracovní prostředí moderního vědeckého centra
  • Přátelský mezinárodní kolektiv
  • Pět týdnů dovolené
  • Příspěvek na stravování

 

Kontaktní informace:

Žádost prosím pošlete e-mailem na adresu: Veronika.Kasparova@ibt.cas.cz

Datum nástupu do zaměstnání: dle dohody v průběhu podzimu 2017.

Pracoviště: GeneCore BIOCEV, Průmyslová 595, 252 50 Vestec, Česká republika

Více informací naleznete na: www.biocev.eu a http://genexp.ibt.cas.cz/serv.html

                                                                                                                

PhD student position

 

The role of protein friction in the dynamics of cytoskeletal filaments

 

The cytoskeleton is the intracellular network of dynamical filaments, interconnected and regulated by associated proteins, that both generates intracellular mechanical forces and withstands forces from the outside. One of the canonical force-generating mechanism in cytoskeleton is the assembly and disassembly of cytoskeletal filaments, termed the filament dynamics. Friction limits the force generation in all mechanical systems, but experimental studies of its effect on the mechanics of cytoskeleton have only just begun. How friction affects filament dynamics, remains an open question.2017_student_flyer.png
 

Project: The project, based on previous results (Lansky, Braun et al. Cell 2015, 160(6): 1159-68 and Braun, Lansky et al. Nat Cell Biol 2011, 13(10): 1259-64), will be focused on quantitative characterization of the effects of friction-generating cytoskeletal proteins on dynamics of cytoskeletal filaments. The individual proteins will be expressed in a recombinant form, combined with cytoskeletal filaments in vitro and the emergent system will be investigated using a combination of advanced biophysical and biochemical experimental techniques such as single molecule fluorescence microscopy and optical tweezers.  


Candidate's profile: Eligible candidates should have a degree in (bio)physics, biology, chemistry or equivalent and should be interested in cross-disciplinary experimental work.
 

Contact: For application or further information please contact Marcus Braun or Zdeněk Lánský:
braun@mpi-cbg.de
zdenek.lansky@ibt.cas.cz
 

Marcus Braun, PhD
BIOCEV
Institute of Biotechnology CAS, v. v. i.
Průmyslová 595, 252 50 Vestec
Czech Republic
www.biocev.eu