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Vědecká pracoviště

The Institute of Biotechnology of the Czech Academy of Sciences (IBT) announces in accordance with the Act no. 283/1992 Coll. on the Academy of Sciences of the Czech Republic, as amended by Act no. 420/2005 Coll. and the Statutes of the CAS an open full-time position

 

PhD and/or Postdoctoral fellow in "Structural Bioinformatics"

 

Requirements:
  • Master/PhD in relevant field (biophysics, physics, physical chemistry, biochemistry, molecular biology...)
  • Proved history of research activities (postdoc)
  • Ability to actively participate in a research program
  • Excellent communication skills and teamwork
  • Readiness for high work load
  • English, written and spoken, advanced level
  • Good repute

 

Job description:
The successful candidate will have a genuine interest in understanding the structural and functional features of biologically relevant molecules and their interactions employing the tools of structural bioinformatics and molecular modeling, including development and testing of necessary computational methods and procedures. Experience with molecular modeling such as homology modeling, molecular dynamics simulations or docking of biological systems is necessary, ability to perform quantum mechanics calculations on biological or organic molecules, and/or programming skills is an advantage.

The successful candidate will work with Jiri Cerny at the IBT as a member of the “Laboratory of Structural Bioinformatics of Proteins” and collaborate with the IBT and BIOCEV based research groups, as well as with external groups on state-of-the-art medically and biotechnologically oriented cross-disciplinary projects.
The contract is offered for three years with a possible extension.
 

Start date: September 2017
 

Workplace location: IBT, Centre of Excellence BIOCEV, Vestec, Prague West region, Czech Republic.
 

IBT is located in the BIOCEV Centre completed in the year 2015, offering access to in house computational resources as well as to the National Grid Infrastructure of the Czech Republic. It is also fully equipped for experimental work in molecular and cellular biology with emphasis on structural and biophysical characterization of studied molecular systems.
 

Send written applications including a cover letter and a professional CV, either in printed or electronic form to address:

Institute of Biotechnology CAS, v. v. i., Prumyslova 595, 25250 Vestec, Czech Republic
btu-office@ibt.cas.cz

 

Application deadline: August 31, 2017

                                                                                                                

Laboratoř inženýrství vazebných proteinů hledá

 

motivované Bc. studenty

 

pro práci v biochemicky orientované laboratoři s možností vypracování bakalářské práce v rámci jednoho ze dvou řešených projektů:

  • Immunomodulatory ligands targeted to IL-23/Th17 pro-inflammatory axis as novel tools for development of topical drugs for treatment of psoriasis
  • Construction of recombinant mimotopes for induction of neutralizing antibodies against HIV-1 gp120 glycoprotein using high-affinity binders approach

 

Pro studenta bude v případě zájmu k dispozici částečný pracovní úvazek.

Informace o laboratoři zde.

V případě zájmu kontaktujte RNDr. Petra Malého, CSc. (email: petr.maly@ibt.cas.cz, tel.: 325 873 763, mobil: 731 648 966).

                                                                                                                

Do našeho týmu hledáme zkušeného laboratorního pracovníka na plný úvazek pro servisní laboratoř GeneCore Biotechnologického ústavu AV ČR, v. v. i. v BIOCEVu, která je předním evropským pracovištěm nabízející qPCR a NGS služby.

 

laboratorní pracovník na plný úvazek

 

Náplň práce:

The laboratory worker will work on client’s projects in molecular analysis mainly with real-time PCR and next generation sequencing technologies. The work encompasses all aspects of workflow from sampling, extraction, quality control, molecular analysis, and data analysis. The laboratory worker also contributes as instructor in hands-on training courses in molecular analyses. The laboratory worker is expected to work independently on projects delegated by the Gene Core manager. The GeneCore facility primarily serves researchers at the BIOCEV campus, but also other researcher in Czech Republic and occasional also international customers. The GeneCore collaborates close with TATAA Biocenter (www.tataa.com).

 

Požadavky:

  • Vysokoškolské vzdělání příslušného směru s odbornou praxí
  • Zájem o technologie a metody pro molekulární analýzy
  • Schopnost pracovat jak samostatně tak i ve skupině
  • Spolehlivost a flexibilita
  • Chuť do práce a odhodlání učit se novým věcem
  • Znalost anglického jazyka slovem i písmem

 

Nabízíme:

  • Pracovní poměr na dobu určitou s možností prodloužení (možné i na zkrácený úvazek)
  • Odpovídající platové ohodnocení
  • Atraktivní pracovní prostředí moderního vědeckého centra
  • Přátelský mezinárodní kolektiv
  • Pět týdnů dovolené
  • Příspěvek na stravování

 

Kontaktní informace:

Žádost prosím pošlete e-mailem na adresu: Veronika.Kasparova@ibt.cas.cz

Datum nástupu do zaměstnání: dle dohody v průběhu podzimu 2017.

Pracoviště: GeneCore BIOCEV, Průmyslová 595, 252 50 Vestec, Česká republika

Více informací naleznete na: www.biocev.eu a http://genexp.ibt.cas.cz/serv.html

                                                                                                                

The Institute of Biotechnology of the Czech Academy of Sciences (IBT) announces in accordance with the Act no. 283/1992 Coll. on the Academy of Sciences of the Czech Republic, as amended by Act no. 420/2005 Coll. and the Statutes of the CAS an open full-time position

 

Postdoctoral fellow of a research project “Dynamics of Biological Processes”

 

Requirements:
  • PhD in biophysics, physics, physical chemistry, biochemistry, or molecular biology
  • Ability to actively participate in a cutting edge research program
  • Publication activity in the field
  • Excellent communication skills and teamwork
  • Readiness for high work load
  • English, written and spoken, advanced level

 

Job description:
The successful candidate will have a genuine interest in understanding the structure and dynamics of nucleic acids and proteins. She or he will participate in interpreting experiments aimed at measuring time-resolved spectra resolving biomolecular dynamics. The experimental approaches include transient absorption, time-resolved vibration spectroscopy such as femtosecond infrared and/or Raman spectroscopy, multidimensional vibration and electronic spectroscopy, and also time-resolved X-ray diffraction. Experience with quantum mechanics calculations of photon and vibrational spectral properties of biological or organic molecules is necessary, ability to perform molecular modeling such as MD or docking of biological systems is an advantage.
The successful candidate will work at IBT and collaborate with the Institute’s research groups. However, time resolved experiments will be designed and executed at ELI-Beamlines in close collaboration with the ELI teams led by Prof. Janos Hajdu and Dr. Jakob Andreasson.
The contract is offered for three years with a possible extension.
 

Start date: September 2017
 

Workplace location: IBT, BIOCEV center, Vestec, and ELI-Beamlines, Dolni Brezany, both Prague West region, Czech Republic.
 

IBT is located in the BIOCEV center completed in the year 2015 and fully equipped for experimental and computational work in molecular and cellular biology with emphasis on structural and biophysical characterization of studied molecular systems. ELI-Beamlines is located about 5 km from BIOCEV and offers opportunity for breakthrough measurements of time-resolved molecular properties using radiation from THz frequencies to X-rays with up to femtosecond resolution. A close collaboration between complementary IBT and ELI-Beamlines teams and their physical closeness opens up a unique opportunity to perform biophysical experiments with medical and biotechnological goals by using technologies of structural biology and photon physics not available elsewhere.
 

Send written applications including a cover letter and a professional CV, either in printed or electronic form to address:

Dr. Bohdan Schneider, Institute of Biotechnology CAS, v. v. i., Prumyslova 595, 25250 Vestec, Czech Republic
bohdan.schneider@ibt.cas.cz

 

Application deadline: August 13, 2017

                                                                                                                

PhD student position

 

The role of protein friction in the dynamics of cytoskeletal filaments

 

The cytoskeleton is the intracellular network of dynamical filaments, interconnected and regulated by associated proteins, that both generates intracellular mechanical forces and withstands forces from the outside. One of the canonical force-generating mechanism in cytoskeleton is the assembly and disassembly of cytoskeletal filaments, termed the filament dynamics. Friction limits the force generation in all mechanical systems, but experimental studies of its effect on the mechanics of cytoskeleton have only just begun. How friction affects filament dynamics, remains an open question.2017_student_flyer.png
 

Project: The project, based on previous results (Lansky, Braun et al. Cell 2015, 160(6): 1159-68 and Braun, Lansky et al. Nat Cell Biol 2011, 13(10): 1259-64), will be focused on quantitative characterization of the effects of friction-generating cytoskeletal proteins on dynamics of cytoskeletal filaments. The individual proteins will be expressed in a recombinant form, combined with cytoskeletal filaments in vitro and the emergent system will be investigated using a combination of advanced biophysical and biochemical experimental techniques such as single molecule fluorescence microscopy and optical tweezers.  


Candidate's profile: Eligible candidates should have a degree in (bio)physics, biology, chemistry or equivalent and should be interested in cross-disciplinary experimental work.
 

Contact: For application or further information please contact Marcus Braun or Zdeněk Lánský:
braun@mpi-cbg.de
zdenek.lansky@ibt.cas.cz
 

Marcus Braun, PhD
BIOCEV
Institute of Biotechnology CAS, v. v. i.
Průmyslová 595, 252 50 Vestec
Czech Republic
www.biocev.eu

                                                                                                                

PhD student position

 

Physiological functions of GCPII orthologs in basal organisms

 

Summary: Human glutamate carboxypeptidase II (GCPII) is a zinc-dependent peptidase that is increasingly recognized as a target of therapeutic interventions in a variety of neurologic disorders as well as a marker for imaging and therapy of prostate cancer. However, despite of nearly universal expression of GCPII-like protein in living organism there is limited knowledge of physiological function(s) of its orthologs in non-mammalian species.
 

Project: The project focuses on structure-function studies of non-mammalian orthologs of human GCPII, including enzymes from C.elegans, F.hepatica, D.rerio, A. thaliana, S.mansoni and yeast species. Used methodology includes cloning strategies (Gateway), mutagenesis, heterologous protein expression in various systems (E.coli, K.lactis, insect and mammalian cells), protein purification and characterization, enzymatic assays including high-throughput library screening, inhibition studies, cell biology (fluorescent microscopy), and X-ray crystallography. We believe that unravelling physiological function(s) of these proteins in non-mammalian species could shed light unto yet unknown functions of the protein in mammals, including humans.
 

Qualifications: Applicants should have a solid background in molecular biology and biochemistry or cell biology. We expect good communication skills, analytical thinking and the ability for teamwork. The successful candidate will participate in a PhD program at Charles University in Prague. The starting date is summer/fall 2016.

 

How to Apply: For more information please contact Cyril Bařinka (cyril.barinka@ibt.cas.cz) directly.

 

Cyril Barinka, PhD
Laboratory of Structural Biology
BIOCEV, Centre of Excellence
25242 Vestec u Prahy
http://academy5.avcr.cz/lsb/

                                                                                                                

PhD student position

 

Molecular basis of substrate recognition by histone deacetylases (HDACs)

 

Summary: Protein acetylation has emerged as a key regulatory mechanism of fundamental cellular processes in all living organisms. However, there is a limited understanding of structural and functional features of the enzymatic machinery (histone acetyltransferase and histone deacetylases) implicated in these processes. Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family and is an attractive target for therapeutic interventions in cancers and neuropathologies. Several HDAC6 substrates have been identified up to date, yet our understanding of HDAC6 cellular functions is quite limited.


Project: The project focuses on unraveling the molecular basis of the substrate recognition by HDAC6. We have successfully established a methodology for heterologous production of HDAC6 variants in a mammalian expression system. A set of molecular biochemical and biophysical approaches will be harnessed to define general principles governing substrate recognition by HDAC6.


Job description: We are seeking a highly motivated PhD candidate to join our research team investigating a structure and function of human HDAC6 and related enzymes. We are using methods of molecular biology (cloning, mutagenesis, heterologous expression), biochemistry (protein purification, enzymatic assays), and biophysics (surface plasmon resonance, thermophoresis, X-ray crystallography, electron microscopy) to unravel fundamental molecular characteristics of HDAC6 and related deacetylases.


Qualifications: Applicants should have a solid background in molecular biology and biochemistry or cell biology. We expect good communication skills, analytical thinking and the ability for teamwork. The successful candidate will participate in a PhD program at Charles University in Prague. The starting date is summer/fall 2016.


How to Apply: For more information please contact Cyril Bařinka (cyril.barinka@ibt.cas.cz) directly.

 

Cyril Barinka, PhD
Laboratory of Structural Biology
BIOCEV, Centre of Excellence
25242 Vestec u Prahy
http://academy5.avcr.cz/lsb/