Pushing science to the real world - medicinal chemistry, technology transfer and drug development
Service Technology Laboratory
The Service Technology Laboratory (STL) is a core facility focused mainly on medicinal chemistry, preclinical development and advanced technology transfer. STL is a member of the AV21-CAS strategy for preclinical evaluation of potential new drugs that identifies molecules suitable for further development in medical applications or biological tools.
Our job is to design and synthesize new potentially biologically active substances which are used by our collaborators for basic or applied research. Our experience includes in vitro screening of newly prepared substances and evaluation of Structure Activity Relationship (SAR); basic toxicological assessments in vivo such as Maximum Tolerated Dose studies (MTD), pharmacokinetic studies (FK) and also pilot pharmacodynamics studies.
Our laboratory also provides services beyond common academic research, mainly relevant to advanced drug development and clinical trials.
We synthesize substances, impurities and metabolites in certified quality suitable for advanced preclinical evaluation under the GLP system. We have experience with a process scale-up as well as with a process transfer for GMP manufacturing.
Our most advanced product – MitoTam is currently in phase 1 clinical trial where STL provides administrative and technical support. The vast body of documentation prepared in our laboratory has been successfully audited and approved by the State Institute for Drug Control.
STL also offers custom syntheses in the field of organic chemistry either on a contract basis or as a part of academic collaboration.
- design and synthesis of new potentially biologically active substances
- in vitro screening of newly prepared substances
- advanced drug development and clinical trials.
- synthesizs of substances, impurities and metabolites in certified quality suitable for advanced preclinical evaluation under the GLP system
- process scale-up
- process transfer for GMP manufacturing.