Myomedins as immunogens elicit HIV-1 neutralizing antibodies

Recently we have proposed “Non-cognate Ligand Strategy (NCLS) as a promising approach for the development of scaffold-derived epitope-mimicking proteins as vaccine immunogens. To support this approach, we developed a set of proteins called Myomedins that stimulated production of HIV-1 neutralizing antibodies in immunized mice. These variants mimic gp41/Env epitope recognized by broadly neutralizing antibody 10E8 and have potential to serve as HIV-1 vaccine components.

For details see:

https://www.tandfonline.com/doi/full/10.1080/21505594.2021.1920251