Our laboratories offer a range of techniques for the production, characterisation and measurement of biological macromolecule samples as a service to external parties.
Ing. Jan Dohnálek, Ph.D.
phone: +325 873 758
RNDr. Lubica Škultétyová, Ph.D.
phone: +325 873 780
Properties of biomolecules: size distribution, structure, stability and conformation
Sample quality (aggregation), particle size and molecular weight estimate, ratio of components in the case of mixtures. Offers measurement of the particle size distribution in solution, particle oligomerization, aggregation.
Mass spectrometry of biomolecules
Identification of proteins in complex mixtures and their relative quantification. Determination of recombinantly expressed or isolated proteins. Characterization of protein modifications. Determination of protein-protein interaction areas and structural changes by hydrogen-deuterium exchange and chemical cross-linking in combination with mass spectrometry.