Finished plasmid DNA, sequencing results confirming cloning success. Bacterial pellets containing the desired protein. Purified protein sample.
Properties of biomolecules: size distribution, structure, stability and conformation
Sample quality (aggregation), particle size and molecular weight estimate, ratio of components in the case of mixtures. Offers measurement of the particle size distribution in solution, particle oligomerization, aggregation.
Mass spectrometry of biomolecules
Identification of proteins in complex mixtures and their relative quantification. Determination of recombinantly expressed or isolated proteins. Characterization of protein modifications. Determination of protein-protein interaction areas and structural changes by hydrogen-deuterium exchange and chemical cross-linking in combination with mass spectrometry.