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Superspecialized mitochondria of Giardia intestinalis

Each year, the student organization ADIC (Association of PhD Students and Young Post-Docs of Institut Curie) collaborates with a top European institution for this retreat. This time around, they've chosen to partner with IBT and The Centre de Recherche des Cordeliers (CRC).

Mitochondria harbour two important pathways: the Krebs cycle and oxidative phosphorylation (OXPHOS). While Krebs cycle is a hub of catabolic and anabolic pathways essential for proper physiology and function of a cells, OXPHOS is the major source of cellular energy in the for of ATP. Thus, the two pathways are under strict control. They are connected with each other by mitochondrial respiratory complex II (CII), also referred to as succinate de-hydrogenase (SDH). ...

Unraveling the architecture of ASK1: insight into TRX1-mediated regulation

Engineering of antibody-based theranostic molecules targeted to prostate cancer

“SAXS and SONICC: Two techniques helping in Structural Biology”

The role of miRNAs in spinal cord injury: A novel therapeutic approach or diagnostic criterion?

No Swimming, No Life: New Insights into Sperm Immotility

Structural Bioinformatics of Nucleic Acids: The Sleeper Must Awaken

How to resolve fuzzy complex with protein engineering

This basic-level school is aimed at biologists, biophysicists, biochemists, structural biologists, etc., who want to learn a technique enabling high throughput screening for dynamic parameters of biochemical interactions on a single molecule level.

Horizontal mitochondrial transfer in the tumor microenvironment and the role of Miro1

Identification of novel pathways regulating transition between proliferation and quiescence of breast cancer cells

Mitochondrial iron chelation as an anticancer therapy: The role of the NDRG1 tumor suppressor

Cancer-associated fibroblasts and their role in cancer

When will RNA get its AlphaFold moment?

obsah se připravuje

The President of the Czech Science Foundation (GACR) together with the Minister for Science, Research and Innovation awarded the five best scientific projects at the 20th anniversary ceremony of the Czech Science Foundation President's Awards yesterday (12 October 2023) at the Martinský Palace. The award recipients from all areas of basic research have contributed to a significant expansion of knowledge in the field and will lead to further applications.

Scientists from the Institute of Biotechnology (BTU) of the CAS at the Biotechnology and Biomedicine Centre of the Czech Academy of Sciences and Charles University (BIOCEV) and the Institute of Clinical and Experimental Medicine (IKEM) have elucidated the crucial role of the NEUROD1 protein in the development of severe diabetes. MODY6 diabetes is a subtype of diabetes caused by a mutation in the neurogenic differentiation factor 1 (NEUROD1) gene. ...

For the excellent results of the project "The role of NEUROD1 and ISL1 in the development of inner ear neurons" Gabriela Pavlínková received an honorary recognition from the President of the Grant Agency of the Czech Republic (GAČR) last week.

Cancer cells need an immense amount of building material to proliferate. When they run out, they are able to persuade healthy nearby cells to supply them. How they do so is the subject of research done by Kateřina Rohlenová from the Institute of Biotechnology of the CAS: “We already know quite well what happens on the inside of cancer cells. We now want to map what happens in their surroundings. ...

During his stay in the Czech Republic, Nobel Prize winner in Physiology and Medicine Professor Gregg L. Semenza visited IBT at the BIOCEV center. It was the first visit of a Nobel Prize winner in the history of the center and his lecture on "Hypoxia-inducible factors in Physiology and medicine" filled the conference hall to the last seat.

Centrum molekulární struktury spolu s odborníky z CCP4 pořádá praktický kurz o softwaru CCP4

The first IBT Student Day- an informal event to discuss science, encourage new connections and foster collaborations between the IBT labs

Reproduction in research and clinical practice

The application of label-free biophysical techniques, such as Isothermal Titration Calorimetry (ITC), Label-Free Microscale Thermophoresis (LF MST), and Differential Scanning Fluorimetry (DSF) for the characterization of protein interactions.

The Dresden International Graduate School for Biomedicine and Bioengineering (DIGS-BB) and four institutes of the Academy of Sciences of the Czech Republic have started a new collaboration on the education of doctoral students.

The end of the year is a time of social gatherings. And so, after a two-year covid break, we met together with the IBT management to evaluate the past year and look to the future.

The latest upgrades, instruments, and staff changes of the Centre of Molecular Structure

The most prestigious scientific grant awarded by the European Research Council, the ERC Synergy Grant, goes to the team of Zdenek Lánský from the Institute of Biotechnology of the Czech Academy of Sciences in the BIOCEV center. With French and American colleagues, he will investigate the function of a protein called tubulin, which is significantly involved in the transport of substances inside cells. ...

Practical course in single cell mass spectrometry and data processing

Workshop on the proteins stability and size determination by Prometheus Panta and biomolecular interaction characterization by Monolith NT.115. Presentation of techologies and advanced features of the new devices Panta and Dianthus (start at 10 a.m. on 4th of October, Seminar room U1.032) will be followed by the hands-on workshop (laboratory I1.018). Stability measurement using Prometheus Panta - 4th of October. ...

A new study focused on the structure and function of natural killer cell surface receptors was recently published in the prestigious journal Nature Communications. The study comes from the research teams of Dr. Ondřej Vaněk from the Department of Biochemistry, Faculty of Science, Charles University, and Dr. Jan Dohnálek from the Institute of Biotechnology of the Czech Academy of Sciences.

A new protein that plays a key role during sperm-egg adhesion and fusion has been discovered by an international team led by Kateřina Komrsková from the Institute of Biotechnology of the Czech Academy of Sciences at the BIOCEV Centre and the Faculty of Science of Charles University in Prague. The researchers also developed special cell cultures for the “production” of human oocyte proteins. ...

Small angle X-ray scattering is a powerful method for in solution characterization of macromolecular structures. The course will provide practical experience with the data collection and processing. The data processing will focus on usage of ATSAS software package. Participants are encouraged to bring their own laptops. Application: Please, apply at the following link: HERE The number of participants is limited. ...

Experts from NanoTemper company are organizing a workshop on the characterization of biomolecular interaction by the Microscale Thermophoresis technique and protein stability with particle size determination by Prometheus Panta.

The aim of the two-day meeting held on June 2-3 was to evaluate the research results and plans for further activities of six research laboratories, i.e. half of the Institute of Biotechnology operating in the BIOCEV center. Members of the Scientific Advisory Board of the Institute of Biotechnology of the CAS (SAB) and two external members of the IBT Board met for this purpose for the first time since the establishment of the SAB in 2021.

A basic overview and hands-on experience in methods of protein crystallization available in CMS.

A team of scientists and physicians from the Institute of Biotechnology of the CAS at the BIOCEV centre and the Institute of Clinical and Experimental Medicine in Prague has demonstrated a positive effect of MitoTam on type 2 diabetes. The research was published in the prestigious journal Nature Communications.

A research team led by Professor Jiří Neužil from the Institute of Biotechnology of the Academy of Sciences of the Czech Republic at the BIOCEV center described the effect of the Czech anti-cancer substance MitoTam in combination with immunotherapy on kidney tumors.

Introduce the Centre of Molecular Structure (CMS) and its services to potential users

#ScienceForUkraine is a community group of volunteer students and research scientists from academic institutions in Europe and around the world. Its mission is to collect and disseminate information about support opportunities at the university, national, and international level for graduate students and researchers directly affiliated to an academic institution in Ukraine. ...

In an open letter the Institute of Biotechnology of the Czech Academy of Sciences appeals to Russian scientists to strongly condemn the aggression against Ukraine.

The XVIII Discussions in Structural Molecular Biology and the 5th User Meeting of CIISB will be held in Nove Hrady, South Bohemia, on 24-26 March 2022 . The whole program takes place at Nový Zámek.

This year, six group leaders have received EMBO Installation Grants. One of them, and the only recipient in the Czech Republic, is Kateřina Rohlenová from the Institute of Biotechnology AS CR in the BIOCEV centre, who is also a recent holder of a prestigious ERC grant.

Mgr. Katerina Rohlenova, Ph.D. from the Institute of Biotechnology of the Czech Academy of Sciences at the BIOCEV Centre has been awarded the most prestigious European scientific grant by the European Research Council (ERC). She will receive EUR 1.5 million (approximately CZK 38 million) over five years for her innovative research into metabolic communication in tumours.

Testing of samples for the presence of SARS-CoV-2 virus by PCR in the BIOCEV centre is available only for employees of the Czech Academy of Sciences and Charles University who work at the Biotechnology and Biomedicine Centre in Vestec. Interested members of the public, companies and other institutions can use testing centres in the vicinity of BIOCEV and Prague.

Dear colleagues, I am taking the liberty of letting you know that on November 25-28, we will organize international biannual conference Mitochondria, Apoptosis and Cancer 2021 (MAC'21) that will be run virtually by our friends from the National University of Singapore. Participation is free of charge and information about the conference is at www.mac21.org. For your information, the inaugural conference, MAC'09, and then MAC'19 were held in Prague. Wish you a pleasant day. prof. Jiri Neuzil

One of the few projects that the Grant Agency of the Czech Republic will support within the JUNIOR STAR competition starting 2022 is project "Intercellular communication of nucleotides: a neglected goal for new anti-cancer approaches".

Excellent scientists have received the Award of the President of the Czech Science Foundation (GACR) for outstanding results in grant projects, which was exceptionally presented this year by GACR Vice President Stanislava Hronová. The prestigious prize for the best basic research was awarded to Zdeněk Lánský (Institute of Biotechnology of the Czech Academy of Sciences)

On October 14-15 application specialists from Sartorius company will give a presentation about the Bio-Layer Interferometry technology followed by the experiments of biomolecular interaction on OCTET system and data processing training.

On Thursday, September 30, the Institute of Biotechnology welcomed a distinguished guest, Noel Barrett.

On October 12 the Centre of Molecular Structure with experts from NanoTemper company are holding a demonstration of the Prometheus Panta for protein stability with particle size determination and of the new Monolith MST device with better temperature control for the characterization of biomolecular interaction.

The Institute of Biotechnology (IBT) and the Institute of Organic Chemistry and Biochemistry (IOCB Prague), both part of the Czech Academy of Sciences, have signed a licensing agreement with the company Immunotech, a subsidiary of Beckman Coulter, for the manufacture and distribution of a newly developed coronavirus antibody IVD test. ...

A new study from the Institute of Biotechnology’s Molecular Therapeutics Laboratory led by Prof. Jiří Neužil in collaboration with Prof. Karel Pacák’s group from the National Institute of Health (Bethesda, MD, USA), which led to the discovery of eight SUCLG2 gene variants in patients with neuroendocrine tumours, puts SUCLG2 on the list of genes whose pathogenic germline variations may increase the risk of cancer development due to misregulation of cellular metabolism. ...

Contractility is an essential biological process enabling cells to divide, move and change their shape. The established understanding of cell contractility is based on the action of myosin motor proteins sliding actin filaments relative to each other. ...

On the 1st of July 2021 the molecular-scale biophysics EU programme MOSBRI commences operation.

CMS introduces new crystallization hotel RI182 dedicated to low temperatures

Recently we have proposed “Non-cognate Ligand Strategy (NCLS) as a promising approach for the development of scaffold-derived epitope-mimicking proteins as vaccine immunogens. To support this approach, we developed a set of proteins called Myomedins that stimulated production of HIV-1 neutralizing antibodies in immunized mice. These variants mimic gp41/Env epitope recognized by broadly neutralizing antibody 10E8 and have potential to serve as HIV-1 vaccine components. ...

The Centre of Molecular Structure (CMS) would like to invite you to a IUCr satelite joint workshop with CCP4/CCP-EM.

The congress principal topics are Biological and macromolecular crystallography; Physics and fundamental crystallography; Materials and minerals; Chemical crystallography, crystal structures; Methods and instruments; Theory, computation, modelling, data, standards.

Webinar of CMS and the Swedish company Excillum

The team of the Laboratory of Tumour Resistance and Service technology laboratory (both Institute of Biotechnology, Czech Academy of Sciences (IBT, CAS) has developed a novel anti-cancer drug that interferes with mitochondrial iron metabolism. ...

Read an Open letter to the Minister of Education, Youth and Sports, a kind request for support of EMBO grants for the Czech Republic in the form of increasing the number of awarded EMBO installation grants to two to three newly supported grants per year and securing funds for their implementation from the state budget.

The Centre of Molecular Structure would like to invite you to an Instruct-ERIC course in Biophysics, structural mass spectrometry, and X-ray techniques.

The Centre of Molecular Structure introduces its newsletter with updates on its core facilities: new instruments, upgrades of current instruments, or the brand new Protein Production facility. You will find details in attachment. You can realize your projects at CMS via an online application at ciisb.org/open-access/proposal-submission Find out more information at ciisb.org, ibt.cas.cz/core-facility/CMS/ or contact magdalena.schneiderova@ibt.cas.cz, jan.dohnalek@ibt.cas. ...

The Institute of Biotechnology of the Czech Academy of Sciences, together with the Faculty of Science, Charles University, offers regular COVID-19 testing for businesses. The test analyses a saliva sample using the PCR technology (testing for the direct presence of a virus’s genetic code in a sample) using certified test kits supplied by the Czech company DIANA Biotechnologies s.r.o. It is the most reliable method that does not require an unpleasant nasopharyngeal swab. ...

XDSkappa: diffraction data processing from laboratory instrument

The European Union’s Horizon 2020 INFRAIA programme has awarded a 5 M€ infrastructure grant to MOSBRI (Molecular-Scale Biophysics Research Infrastructure www.mosbri.eu), a consortium of 13 academic centres of excellence and 2 industrial partners from 11 different European countries, coordinated by Institut Pasteur (Paris, France).

The research team of Dr. Kateřina Komrsková from the Institute of Biotechnology of the Academy of Sciences of the Czech Republic at the BIOCEV centre, which studies causes of infertility, has filed two international patents that are of key importance for the advancement of assisted reproduction. The first patent documents how to determine sperm quality with extreme accuracy. ...

At the end of last year, the Czech Science Foundation (GAČR) completed an evaluation of project proposals accepted for public tender in research, experimental development and innovation to support basic research grant projects.

A proof of concept methodology to identify protein structures that could be converted into engineered protein scaffolds.