A basic overview and hands-on experience in methods of protein crystallization available in CMS.
News and Events
Czech anticancer agent works on type 2 diabetes
A team of scientists and physicians from the Institute of Biotechnology of the CAS at the BIOCEV centre and the Institute of Clinical and Experimental Medicine in Prague has demonstrated a positive effect of MitoTam on type 2 diabetes. The research was published in the prestigious journal Nature Communications.
New strategy for renal cancer therapy
A research team led by Professor Jiří Neužil from the Institute of Biotechnology of the Academy of Sciences of the Czech Republic at the BIOCEV center described the effect of the Czech anti-cancer substance MitoTam in combination with immunotherapy on kidney tumors.
The European platform of job vacancies for Ukrainian researchers
#ScienceForUkraine is a community group of volunteer students and research scientists from academic institutions in Europe and around the world. Its mission is to collect and disseminate information about support opportunities at the university, national, and international level for graduate students and researchers directly affiliated to an academic institution in Ukraine. ...
Kateřina Rohlenová received EMBO Installation Grants
This year, six group leaders have received EMBO Installation Grants. One of them, and the only recipient in the Czech Republic, is Kateřina Rohlenová from the Institute of Biotechnology AS CR in the BIOCEV centre, who is also a recent holder of a prestigious ERC grant.
The head of the youngest research group from IBT at the BIOCEV centre has ...
Mgr. Katerina Rohlenova, Ph.D. from the Institute of Biotechnology of the Czech Academy of Sciences at the BIOCEV Centre has been awarded the most prestigious European scientific grant by the European Research Council (ERC). She will receive EUR 1.5 million (approximately CZK 38 million) over five years for her innovative research into metabolic communication in tumours.
COVID-19 testing at BIOCEV for employees only
Testing of samples for the presence of SARS-CoV-2 virus by PCR in the BIOCEV centre is available only for employees of the Czech Academy of Sciences and Charles University who work at the Biotechnology and Biomedicine Centre in Vestec. Interested members of the public, companies and other institutions can use testing centres in the vicinity of BIOCEV and Prague.
The seventh conference Mitochondria, Apoptosis and Cancer 2021
Dear colleagues, I am taking the liberty of letting you know that on November 25-28, we will organize international biannual conference Mitochondria, Apoptosis and Cancer 2021 (MAC'21) that will be run virtually by our friends from the National University of Singapore. Participation is free of charge and information about the conference is at www.mac21.org. For your information, the inaugural conference, MAC'09, and then MAC'19 were held in Prague. Wish you a pleasant day. prof. Jiri Neuzil
Zdeněk Lánský received the Czech Science Foundation President’s Award for ...
Excellent scientists have received the Award of the President of the Czech Science Foundation (GACR) for outstanding results in grant projects, which was exceptionally presented this year by GACR Vice President Stanislava Hronová. The prestigious prize for the best basic research was awarded to Zdeněk Lánský (Institute of Biotechnology of the Czech Academy of Sciences)
Prometheus Panta and Monolith MST demonstration
On October 12 the Centre of Molecular Structure with experts from NanoTemper company are holding a demonstration of the Prometheus Panta for protein stability with particle size determination and of the new Monolith MST device with better temperature control for the characterization of biomolecular interaction.
License for new precision test for antibodies protecting against coronavirus
The Institute of Biotechnology (IBT) and the Institute of Organic Chemistry and Biochemistry (IOCB Prague), both part of the Czech Academy of Sciences, have signed a licensing agreement with the company Immunotech, a subsidiary of Beckman Coulter, for the manufacture and distribution of a newly developed coronavirus antibody IVD test. ...
Pathogenic variation in the SUCLG2 gene increases the risk of rare ...
A new study from the Institute of Biotechnology’s Molecular Therapeutics Laboratory led by Prof. Jiří Neužil in collaboration with Prof. Karel Pacák’s group from the National Institute of Health (Bethesda, MD, USA), which led to the discovery of eight SUCLG2 gene variants in patients with neuroendocrine tumours, puts SUCLG2 on the list of genes whose pathogenic germline variations may increase the risk of cancer development due to misregulation of cellular metabolism. ...
Myomedins as immunogens elicit HIV-1 neutralizing antibodies
Recently we have proposed “Non-cognate Ligand Strategy (NCLS) as a promising approach for the development of scaffold-derived epitope-mimicking proteins as vaccine immunogens. To support this approach, we developed a set of proteins called Myomedins that stimulated production of HIV-1 neutralizing antibodies in immunized mice. These variants mimic gp41/Env epitope recognized by broadly neutralizing antibody 10E8 and have potential to serve as HIV-1 vaccine components. ...
25th Congress of the International Union of Crystallography
The congress principal topics are Biological and macromolecular crystallography; Physics and fundamental crystallography; Materials and minerals; Chemical crystallography, crystal structures; Methods and instruments; Theory, computation, modelling, data, standards.
Targeting mitochondrial iron metabolism as a new anti-cancer strategy
The team of the Laboratory of Tumour Resistance and Service technology laboratory (both Institute of Biotechnology, Czech Academy of Sciences (IBT, CAS) has developed a novel anti-cancer drug that interferes with mitochondrial iron metabolism. ...
Researchers Led by CEITEC Are Asking the Minister of Education for Support ...
Read an Open letter to the Minister of Education, Youth and Sports, a kind request for support of EMBO grants for the Czech Republic in the form of increasing the number of awarded EMBO installation grants to two to three newly supported grants per year and securing funds for their implementation from the state budget.
CMS Newsletter March 2021
The Centre of Molecular Structure introduces its newsletter with updates on its core facilities: new instruments, upgrades of current instruments, or the brand new Protein Production facility. You will find details in attachment. You can realize your projects at CMS via an online application at ciisb.org/open-access/proposal-submission Find out more information at ciisb.org, ibt.cas.cz/core-facility/CMS/ or contact firstname.lastname@example.org, email@example.com. ...
COVID-19 testing for businesses
The Institute of Biotechnology of the Czech Academy of Sciences, together with the Faculty of Science, Charles University, offers regular COVID-19 testing for businesses. The test analyses a saliva sample using the PCR technology (testing for the direct presence of a virus’s genetic code in a sample) using certified test kits supplied by the Czech company DIANA Biotechnologies s.r.o. It is the most reliable method that does not require an unpleasant nasopharyngeal swab. ...
Centre of Molecular Structure of the IBT will be part of the new European ...
The European Union’s Horizon 2020 INFRAIA programme has awarded a 5 M€ infrastructure grant to MOSBRI (Molecular-Scale Biophysics Research Infrastructure www.mosbri.eu), a consortium of 13 academic centres of excellence and 2 industrial partners from 11 different European countries, coordinated by Institut Pasteur (Paris, France).
Research on the CD46 protein moves assisted reproduction towards the ...
The research team of Dr. Kateřina Komrsková from the Institute of Biotechnology of the Academy of Sciences of the Czech Republic at the BIOCEV centre, which studies causes of infertility, has filed two international patents that are of key importance for the advancement of assisted reproduction. The first patent documents how to determine sperm quality with extreme accuracy. ...
Researchers from IBT and IEM CAS have received the prestigious EXPRO 2021 grant
At the end of last year, the Czech Science Foundation (GAČR) completed an evaluation of project proposals accepted for public tender in research, experimental development and innovation to support basic research grant projects.
Instruct-ERIC ‘Structure Meets Function’ webinar - register now
Featuring expert speakers from Instruct Centres across Europe, the Instruct-ERIC webinar series, Structure Meets Function, highlights some of the latest developments in structural biology, demonstrating how integrative methods are enabling scientists to decipher the mechanisms that underpin health and disease.
ELIBIO Laboratory Opening
The Biological Laboratory of the ELIBIO project at ELI Beamlines was officially opened 20th of January 2021 by Robert Plaga the Minister of Education, Youth and Sports, Eva Zažímalová the President of the Czech Academy of Sciences and Michael Prouza Director of the Insitute of Physics of the Czech Academy of Sciences.
Online applications of new research projects into CMS newest facility ...
The Centre of Molecular Structure has launched online applications of new research projects into its newest facility Protein Production. If you wish to use the services of Protein Production or any of our other facilities, submit your application via the CIISB online form.
New possibilities in fight against pathogenic bacteria
Three international research teams succeded in elucidation of a unique molecular mechanism, which enables bacteria, including pathogens, to maintain the flow of genetic information from DNA to RNA. The discovery leads to new possibilities of development of the much needed antimicrobials against serious pathogens, including the causative agent of tuberculosis. Their discoveries have been published in the journal Nature Communications.
The new laboratory of IBT CAS will focus on the metabolism of healthy ...
In October 2020 a new research group started at the Institute of Biotechnology (IBT) of the Czech Academy of Sciences located at the BIOCEV center. Head of the group, Dr. Katerina Rohlenova, returned to the Czech Republic after a postdoctoral stay in the laboratory of Prof. Peter Carmeliet at the Center for Cancer Biology (VIB-KU Leuven) in Belgium, where she studied metabolism of cells that form blood vessels in tumors. At IBT Katerina teamed-up with Dr. ...
Mitochondria move smoothly through crowded environment
An international team led by researchers from the Institute of Biotechnology of the Czech Academy of Sciences describes a mechanism underlying transport of organelles within cells. The work shows how long-range transport can efficiently work in crowded cellular environments.
Age-dependent response to stroke characterized in mouse model
Cerebral stroke is one of the leading causes of death and long-term disability worldwide. It affects primarily the elderly population and is typically recognized as a disease associated with aging. However, it remains unknown how such an age-dependent vulnerability develops, and what are the underlying mechanisms. ...
Data analysis with program PAIREF leads to more accurate structures of ...
Diffraction methods are capable to determine 3D atomic structures of biomolecules (e.g. proteins and DNA), essential for the design of drugs and biotechnological applications, etc. A new tool PAIREF, developed at CTU in close collaboration with IBT, provides a comprehensive analysis of experimental data resolution that leads to an optimal accuracy of the structures.
Testing samples for the presence of Covid-19
Scientists from the Institute of Biotechnology of the Academy of Sciences are part of the team of the BIOCEV center, which is led by RNDr. Ruth Tachezy has developed and validated a new reliable SARS-CoV-2 virus detection procedure that allows up to hundreds of samples to be evaluated daily from hospital patients and nursing home clients.
PRAHA TV - Guest of the day: Jaroslav Truksa, Iron metabolism of tumor cells
If the cancer cells have little or extremely much iron, they will not be able to cope and die, "describes one of the possible future strategies to fight cancer Mgr. JAROSLAV TRUKSA, Ph.D. D., from the Institute of Biotechnology of the CAS.
Instruct-ERIC workshop on Computational Approaches in Integration of ...
From 8 to 10 October, the Institute of Biotechnology of the Academy of Sciences of the Czech Republic organized a workshop funded by the European research infrastructure Instruct - ERIC on computational approaches in the integration of structural biology techniques. The event was attended by 20 registered participants and 18 speakers.
Our scientists collaborate on HIF research with this year's Nobel laureate ...
This year's Nobel Prize for Physiology and Medicine goes to the Americans William G. Kaelin and Gregg L. Semenza and the British Sir Peter J. Ratcliffe, whose discoveries made it possible to understand the essence of one of the key adaptive systems for human and other animal life. They have discovered the molecular mechanisms by which cells sense and respond to available oxygen levels.
Dysregulated HIF-1α expression may contribute to cardiac dysfunction
The sympathetic nervous system plays a critical role in stimulating heart rate and contractility to increase cardiac output and thereby insure adequate tissue O2 delivery. Altered sympathetic output contributes to cardiac pathologies, such as sudden cardiac death ...
Hearing without frequencies: gene mutation detunes tonotopic organization ...
Sensory systems develop primary topographic maps of sensory inputs that are projected by sensory neurons to the brain, for example topographical maps of the skin and retina, somatosensory space, and auditory tonotopic map according to sound frequency.
A new role of mitochondria in tumor growth
Researchers from the Institute of Biotechnology of the ASCR at the BIOCEV recently showed that cancer cells with mitochondrial DNA (mtDNA) disorders must regain respiration by "stealing" mitochondria with undamaged mtDNA from surrounding, non-cancerous cells after introduction into laboratory mice.
Involvement of IBT in the new program of AV21 Strategy
After obtaining the certificate of Good Laboratory Practice (GLP) in January 2017, the Centre for Preclinical Testing (CPT) commenced activities with the support of the Czech Academy of Science (CAS). The primary mission of the CPT is to perform preclinical testing of substances that have successfully passed through basic research, and thus to contribute towards the development of new pharmaceuticals to combat life-threatening diseases, including those currently difficult to cure.
Scientists have forced cancer cells to self-destruct
Czech scientists have never been this close to finding a cure for breast cancer. After four years, they have succeeded in developing an agent that can entirely destroy cells of one of the most aggressive forms of cancer. In the Czech Republic, up to 20% of all breast cancer patients suffer from this form of cancer. The preparation, called MitoTam, has successfully passed laboratory tests and clinical trials. This year, human clinical trials are planned to be launched.
Frontiers in targeted modulation of protein function
On November, 28 - 29, 2016, a symposium "Frontiers in targeted modulation of protein function" was held at the BIOCEV center. The symposium was jointly organized by the Institute of Biotechnology CAS, v. v. i. (IBT) and the Weizmann Institute of Science (WIS) and was financially supported by the Czech Academy of Sciences and the Czech government. Normal 0 21 false false false CS X-NONE X-NONE /* Style Definitions */ table. ...
News on the Centre of Molecular Structure
On 22 September 2016, the Czech Infrastructure for Integrative Structural Biology (CIISB) became a full-fledged INSTRUCT center based on a unanimous decision of the members of the INSTRUCT Council. This huge success will enable the Center for Molecular Structure (CMS) at BIOCEV and the structural-biological service laboratories of CEITEC to offer its services officially under the banner of the INSTRUCT research infrastructure.
Visit of Representatives of the Weizmann Institute of Science
On Tuesday, August 30, 2016, the Institute of Biotechnology of the Czech Academy of Sciences (IBT) was visited by two representatives of the Weizmann Institute of Science (WIS), Prof. Irit Sagi and Dr. Jakub Abramson. To our great delight, invitation to visit IBT was also accepted by His Excellency Israeli Ambassador to the Czech Republic, Gary Koren. The guests were welcome by director of the BIOCEV center, prof. Pavel Martásek, and by IBT group leader Dr. Bohdan Schneider.
Scientists from the WIS visited the CMS
On July 6, 2016, two scientists from the Weizmann Institute of Science (Israel) visited the BIOCEV. Dr. Orly Dym and Prof. Joel Sussman were interested in the D8 Venture diffractometer with its unique combination of high-flux liquid Gallium anode X-ray source, Photon II detector and the ISX plate for in-situ diffraction tests and data collection. All instruments are part of the BIOCEV´s Core Facility – Centre of Molecular Structure (CMS), operated by the Institute of Biotechnology CAS.