Cell microfluidic chip based on high-affinity recombinant protein binders

We report on a unique glass microfluidic Y-system with planar immunocapture channel working in so-called stop-flow dynamic regime.

We demonstrate that recombinant protein ligands can be designed for selective cell immunocapture using a biosensor.

Results can be further exploited in design of microfluidic devices for immunocapture of circulating tumor cells or other rare cell populations. Cell immunocapture microfluidic devices represent a rapidly developing field with many potential applications in medical diagnostics.

https://doi.org/10.1016/j.bios.2020.112784

https://www.sciencedirect.com/science/article/pii/S0956566320307715