On the 1st of July 2021 the molecular-scale biophysics EU programme MOSBRI commences operation.
Myomedins as immunogens elicit HIV-1 neutralizing antibodies
Recently we have proposed “Non-cognate Ligand Strategy (NCLS) as a promising approach for the development of scaffold-derived epitope-mimicking proteins as vaccine immunogens. To support this approach, we developed a set of proteins called Myomedins that stimulated production of HIV-1 neutralizing antibodies in immunized mice. These variants mimic gp41/Env epitope recognized by broadly neutralizing antibody 10E8 and have potential to serve as HIV-1 vaccine components. ...
Targeting mitochondrial iron metabolism as a new anti-cancer strategy
The team of the Laboratory of Tumour Resistance and Service technology laboratory (both Institute of Biotechnology, Czech Academy of Sciences (IBT, CAS) has developed a novel anti-cancer drug that interferes with mitochondrial iron metabolism. ...
Centre of Molecular Structure of the IBT will be part of the new European ...
The European Union’s Horizon 2020 INFRAIA programme has awarded a 5 M€ infrastructure grant to MOSBRI (Molecular-Scale Biophysics Research Infrastructure www.mosbri.eu), a consortium of 13 academic centres of excellence and 2 industrial partners from 11 different European countries, coordinated by Institut Pasteur (Paris, France).
Research on the CD46 protein moves assisted reproduction towards the ...
The research team of Dr. Kateřina Komrsková from the Institute of Biotechnology of the Academy of Sciences of the Czech Republic at the BIOCEV centre, which studies causes of infertility, has filed two international patents that are of key importance for the advancement of assisted reproduction. The first patent documents how to determine sperm quality with extreme accuracy. ...
Researchers from IBT and IEM CAS have received the prestigious EXPRO 2021 grant
At the end of last year, the Czech Science Foundation (GAČR) completed an evaluation of project proposals accepted for public tender in research, experimental development and innovation to support basic research grant projects.
ELIBIO Laboratory Opening
The Biological Laboratory of the ELIBIO project at ELI Beamlines was officially opened 20th of January 2021 by Robert Plaga the Minister of Education, Youth and Sports, Eva Zažímalová the President of the Czech Academy of Sciences and Michael Prouza Director of the Insitute of Physics of the Czech Academy of Sciences.
New possibilities in fight against pathogenic bacteria
Three international research teams succeded in elucidation of a unique molecular mechanism, which enables bacteria, including pathogens, to maintain the flow of genetic information from DNA to RNA. The discovery leads to new possibilities of development of the much needed antimicrobials against serious pathogens, including the causative agent of tuberculosis. Their discoveries have been published in the journal Nature Communications.
Age-dependent response to stroke characterized in mouse model
Cerebral stroke is one of the leading causes of death and long-term disability worldwide. It affects primarily the elderly population and is typically recognized as a disease associated with aging. However, it remains unknown how such an age-dependent vulnerability develops, and what are the underlying mechanisms. ...
Our scientists collaborate on HIF research with this year's Nobel laureate ...
This year's Nobel Prize for Physiology and Medicine goes to the Americans William G. Kaelin and Gregg L. Semenza and the British Sir Peter J. Ratcliffe, whose discoveries made it possible to understand the essence of one of the key adaptive systems for human and other animal life. They have discovered the molecular mechanisms by which cells sense and respond to available oxygen levels.
Dysregulated HIF-1α expression may contribute to cardiac dysfunction
The sympathetic nervous system plays a critical role in stimulating heart rate and contractility to increase cardiac output and thereby insure adequate tissue O2 delivery. Altered sympathetic output contributes to cardiac pathologies, such as sudden cardiac death ...
Hearing without frequencies: gene mutation detunes tonotopic organization ...
Sensory systems develop primary topographic maps of sensory inputs that are projected by sensory neurons to the brain, for example topographical maps of the skin and retina, somatosensory space, and auditory tonotopic map according to sound frequency.
A new role of mitochondria in tumor growth
Researchers from the Institute of Biotechnology of the ASCR at the BIOCEV recently showed that cancer cells with mitochondrial DNA (mtDNA) disorders must regain respiration by "stealing" mitochondria with undamaged mtDNA from surrounding, non-cancerous cells after introduction into laboratory mice.
Scientists have forced cancer cells to self-destruct
Czech scientists have never been this close to finding a cure for breast cancer. After four years, they have succeeded in developing an agent that can entirely destroy cells of one of the most aggressive forms of cancer. In the Czech Republic, up to 20% of all breast cancer patients suffer from this form of cancer. The preparation, called MitoTam, has successfully passed laboratory tests and clinical trials. This year, human clinical trials are planned to be launched.
Success of the Centre of Molecular Structure
On September 22, 2016 the INSTRUCT Council unanimously agreed to grant the Czech Infrastructure for Integrative Structural Biology (CIISB) the status of a full INSTRUCT centre. This enormous success enables to offer the services of the BIOCEV Centre of Molecular Structure (CMS) and of the CEITEC Structural Biology Core Facilities officially under the auspices of the INSTRUCT research infrastructure.
Photography from IBT on ARS cover
Publisher of prestigious magazine Antioxidants & Redox Signaling (IF 8,499 in last 5 years) has decided to put on the cover of this magazine's Volume 22 (No. 11) a photography from a research article written, among others, by researchers from The Institute of Biotechnology CAS, v. v. i.
Tire-pump as an inspiration for possible treatment of tumours
Cell division is one of the basic mechanisms that take place in all living organisms ceaselessly. Its malfunction causes severe disorders such as hereditary diseases or cancer. International team of researchers from Czech Republic, Germany and Netherlands was able to replenish another piece of the puzzle of molecular mechanisms that are important to understand how cell division works. They have informed about their discovery in prestigious research magazine Cell.
Remarkable discovery of Prof. Jiří Neužil's research
A tumor cell with no mitochondrial DNA, which is essential for cell function, is able to obtain mitochondria from another cell, thus restarting respiratory function and renew its tumorous potential. According to web portal IFLScience, this is a discovery that will "rewrite textbooks".