Remarkable discovery in IBT
Fri Jan 23 00:00:00 CET 2015
Event date:
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Research team of Prof. J. Neužil from The Institute of Biotechnology AS CR and Griffith University, Australia, has published a remarkable discovery of tumor cell function in the prestigious journal Cell Metabolism.
A tumor cell with no mitochondrial DNA (i.e. no mitochondria that is a respiratory and energetic center of a cell), which is essential for cell function, is able to obtain this organelle from another cell and thus renew its tumorous potential.
Foto: Stanislava Kyselová, Akademický bulletin
Publication:
Tan, A. S., Baty, J. W., Dong, L., Bezawork-Geleta, A., Endaya,
B., Goodwin, J.,
Bajzikova, M.,
Kovarova, J.,
Peterka, M., Yan, B., Pesdar, E. A., Sobol, M., Filimonenko, A., Stuart, S.,
Vondrusova, M.,
Kluckova, K., Sachaphibulkij, K.,
Rohlena, J., Hozak, P.,
Truksa, J., Eccles, D., Haupt, L. M., Griffiths, L. R.,
Neuzil, J.
*, Berridge, M. V.
Mitochondrial genome
acquisition restores respiratory function and tumorigenic potential in cancer cells without
mitochondrial DNA
Cell Metabolism, 21(1): 81-94, 2015. doi: 10.1016/j.cmet.2014.12.003. ISSN 1550-4131.
Researchers from The Institute of Biotechnology are
underlined.
