The Institute of Biotechnology of the Czech Academy of Sciences (BTÚ) has achieved significant success in the Ministry of Education, Youth and Sports' Operational Programme Jan Amos Komenský (OP JAK) – Intersectoral Cooperation.
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![Czech-German collaboration revealed breakthrough observations in division ... Czech-German collaboration revealed breakthrough observations in division ...](/export/sites/btu/.content/images/mitosis.png_1499001171.png)
Czech-German collaboration revealed breakthrough observations in division ...
International research team led by Libor Macurek (Institute of Molecular Genetics, Czech Academy of Sciences), Robert Grosse (Institute for Clinical and Experimental Pharmacology and Toxicology, University of Freiburg) and Zdenek Lansky (Institute of Biotechnology, Czech Academy of Sciences) identified a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division. ...
![Small protein blockers of human IL-6 receptor slow the growth and spread of ... Small protein blockers of human IL-6 receptor slow the growth and spread of ...](/export/sites/btu/.content/images/BTU-ILUSTRACKY-533.jpg_1499001171.jpg)
Small protein blockers of human IL-6 receptor slow the growth and spread of ...
Scientists from the Institute of Biotechnology have successfully developed novel small protein blockers of human interleukin-6 receptor alpha (IL-6Rα) and, in collaboration with researchers from other academic institutions, extensively functionally tested.
![Myomedin MBA proteins aid in the diagnosis of patients with non-small cell ... Myomedin MBA proteins aid in the diagnosis of patients with non-small cell ...](/export/sites/btu/.content/images/PM.png_1499001171.png)
Myomedin MBA proteins aid in the diagnosis of patients with non-small cell ...
Research team of the Laboratory of Ligand Engineering with its collaborators from Palacky University Olomouc (UPOL) has recently reported on engineering of small PD-1 binding proteins named Myomedins MBA that benefit diagnosis of non-small cell lung carcinoma (NSCLC) patients in vitro and monitoring PD-1 positive cell populations in vivo using positron emission tomography (PET/CT).
![New results concerning a key complex regulating the Krebs cycle and ... New results concerning a key complex regulating the Krebs cycle and ...](/export/sites/btu/.content/images/JN1.png_1499001171.png)
New results concerning a key complex regulating the Krebs cycle and ...
Mitochondria harbour two important pathways: the Krebs cycle and oxidative phosphorylation (OXPHOS). While Krebs cycle is a hub of catabolic and anabolic pathways essential for proper physiology and function of a cells, OXPHOS is the major source of cellular energy in the for of ATP. Thus, the two pathways are under strict control. They are connected with each other by mitochondrial respiratory complex II (CII), also referred to as succinate de-hydrogenase (SDH). ...
![Jakub Rohlena received he Czech Science Foundation President’s Award Jakub Rohlena received he Czech Science Foundation President’s Award](/export/sites/btu/.content/images/Rohlena2.jpg_1499001171.jpg)
Jakub Rohlena received he Czech Science Foundation President’s Award
The President of the Czech Science Foundation (GACR) together with the Minister for Science, Research and Innovation awarded the five best scientific projects at the 20th anniversary ceremony of the Czech Science Foundation President's Awards yesterday (12 October 2023) at the Martinský Palace. The award recipients from all areas of basic research have contributed to a significant expansion of knowledge in the field and will lead to further applications.
![Scientists discover the function of NEUROD1 protein in the development of ... Scientists discover the function of NEUROD1 protein in the development of ...](/export/sites/btu/.content/images/Screenshot-2023-09-26-at-11-22-36-Vedcum-se-podarilo-zjistit-funkci-proteinu-NEUROD1-v-rozvoji-diabetu-Biocev.jpg_1499001171.jpg)
Scientists discover the function of NEUROD1 protein in the development of ...
Scientists from the Institute of Biotechnology (BTU) of the CAS at the Biotechnology and Biomedicine Centre of the Czech Academy of Sciences and Charles University (BIOCEV) and the Institute of Clinical and Experimental Medicine (IKEM) have elucidated the crucial role of the NEUROD1 protein in the development of severe diabetes. MODY6 diabetes is a subtype of diabetes caused by a mutation in the neurogenic differentiation factor 1 (NEUROD1) gene. ...
![Gabriela Pavlínková received the Honorary Recognition of the President of ... Gabriela Pavlínková received the Honorary Recognition of the President of ...](/export/sites/btu/.content/images/FullSizeRender.jpg_1499001171.jpg)
Gabriela Pavlínková received the Honorary Recognition of the President of ...
For the excellent results of the project "The role of NEUROD1 and ISL1 in the development of inner ear neurons" Gabriela Pavlínková received an honorary recognition from the President of the Grant Agency of the Czech Republic (GAČR) last week.
![Researching the way cancer cells communicate brings hope for new treatment Researching the way cancer cells communicate brings hope for new treatment](/export/sites/btu/.content/images/2023-01-26-Katerina-Rohlenova-BIOCEV-fullres-14.jpg_1499001171.jpg)
Researching the way cancer cells communicate brings hope for new treatment
Cancer cells need an immense amount of building material to proliferate. When they run out, they are able to persuade healthy nearby cells to supply them. How they do so is the subject of research done by Kateřina Rohlenová from the Institute of Biotechnology of the CAS: “We already know quite well what happens on the inside of cancer cells. We now want to map what happens in their surroundings. ...
![Visit of Nobel Prize winner Professor Gregg L. Semenza Visit of Nobel Prize winner Professor Gregg L. Semenza](/export/sites/btu/.content/images/DSC_4855_DxO.jpg_1499001171.jpg)
Visit of Nobel Prize winner Professor Gregg L. Semenza
During his stay in the Czech Republic, Nobel Prize winner in Physiology and Medicine Professor Gregg L. Semenza visited IBT at the BIOCEV center. It was the first visit of a Nobel Prize winner in the history of the center and his lecture on "Hypoxia-inducible factors in Physiology and medicine" filled the conference hall to the last seat.
![CMS course: Label-free techniques for the characterization of protein ... CMS course: Label-free techniques for the characterization of protein ...](/export/sites/btu/.content/images/core_facilities/cms/MosbriLogo_FullColour.png_1499001171.png)
CMS course: Label-free techniques for the characterization of protein ...
The application of label-free biophysical techniques, such as Isothermal Titration Calorimetry (ITC), Label-Free Microscale Thermophoresis (LF MST), and Differential Scanning Fluorimetry (DSF) for the characterization of protein interactions.
![An international team with a Czech scientist will cast light on the secret ... An international team with a Czech scientist will cast light on the secret ...](/export/sites/btu/.content/images/thumb-697-362-erc-logo.jpg_1499001171.jpg)
An international team with a Czech scientist will cast light on the secret ...
The most prestigious scientific grant awarded by the European Research Council, the ERC Synergy Grant, goes to the team of Zdenek Lánský from the Institute of Biotechnology of the Czech Academy of Sciences in the BIOCEV center. With French and American colleagues, he will investigate the function of a protein called tubulin, which is significantly involved in the transport of substances inside cells. ...
![Workshop with CMS and NanoTemper Workshop with CMS and NanoTemper](/export/sites/btu/.content/images/CMS-kopie.png_1499001171.png)
Workshop with CMS and NanoTemper
Workshop on the proteins stability and size determination by Prometheus Panta and biomolecular interaction characterization by Monolith NT.115. Presentation of techologies and advanced features of the new devices Panta and Dianthus (start at 10 a.m. on 4th of October, Seminar room U1.032) will be followed by the hands-on workshop (laboratory I1.018). Stability measurement using Prometheus Panta - 4th of October. ...
![Functional clustering of surface receptors of human immune cells Functional clustering of surface receptors of human immune cells](/export/sites/btu/.content/images/Obrazek-3_Figure-3.jpg_1499001171.jpg)
Functional clustering of surface receptors of human immune cells
A new study focused on the structure and function of natural killer cell surface receptors was recently published in the prestigious journal Nature Communications. The study comes from the research teams of Dr. Ondřej Vaněk from the Department of Biochemistry, Faculty of Science, Charles University, and Dr. Jan Dohnálek from the Institute of Biotechnology of the Czech Academy of Sciences.
![Protein named after the mythological goddess Maia plays a key role in the ... Protein named after the mythological goddess Maia plays a key role in the ...](/export/sites/btu/.content/images/BIOCEV-BTU-Katerina-Komrskova-Science-0809.jpg_1499001171.jpg)
Protein named after the mythological goddess Maia plays a key role in the ...
A new protein that plays a key role during sperm-egg adhesion and fusion has been discovered by an international team led by Kateřina Komrsková from the Institute of Biotechnology of the Czech Academy of Sciences at the BIOCEV Centre and the Faculty of Science of Charles University in Prague. The researchers also developed special cell cultures for the “production” of human oocyte proteins. ...
![Bio-SAXS practical course 2022 Bio-SAXS practical course 2022](/export/sites/btu/.content/images/CMS-kopie.png_1499001171.png)
Bio-SAXS practical course 2022
Small angle X-ray scattering is a powerful method for in solution characterization of macromolecular structures. The course will provide practical experience with the data collection and processing. The data processing will focus on usage of ATSAS software package. Participants are encouraged to bring their own laptops. Application: Please, apply at the following link: HERE The number of participants is limited. ...
![Members of the Scientific Advisory Board of the IBT met to evaluate the ... Members of the Scientific Advisory Board of the IBT met to evaluate the ...](/export/sites/btu/.content/images/TomStop_3.jpg_1499001171.jpg)
Members of the Scientific Advisory Board of the IBT met to evaluate the ...
The aim of the two-day meeting held on June 2-3 was to evaluate the research results and plans for further activities of six research laboratories, i.e. half of the Institute of Biotechnology operating in the BIOCEV center. Members of the Scientific Advisory Board of the Institute of Biotechnology of the CAS (SAB) and two external members of the IBT Board met for this purpose for the first time since the establishment of the SAB in 2021.
![Czech anticancer agent works on type 2 diabetes Czech anticancer agent works on type 2 diabetes](/export/sites/btu/.content/images/diabetes-528678_960_720.jpg_1499001171.jpg)
Czech anticancer agent works on type 2 diabetes
A team of scientists and physicians from the Institute of Biotechnology of the CAS at the BIOCEV centre and the Institute of Clinical and Experimental Medicine in Prague has demonstrated a positive effect of MitoTam on type 2 diabetes. The research was published in the prestigious journal Nature Communications.
![New strategy for renal cancer therapy New strategy for renal cancer therapy](/export/sites/btu/.content/images/2021_04_08_Jiri_Neuzil.jpg_1761162170.jpg_1499001171.jpg)
New strategy for renal cancer therapy
A research team led by Professor Jiří Neužil from the Institute of Biotechnology of the Academy of Sciences of the Czech Republic at the BIOCEV center described the effect of the Czech anti-cancer substance MitoTam in combination with immunotherapy on kidney tumors.
![The European platform of job vacancies for Ukrainian researchers The European platform of job vacancies for Ukrainian researchers](/export/sites/btu/.content/images/Science-for-Ukraine.png_1499001171.png)
The European platform of job vacancies for Ukrainian researchers
#ScienceForUkraine is a community group of volunteer students and research scientists from academic institutions in Europe and around the world. Its mission is to collect and disseminate information about support opportunities at the university, national, and international level for graduate students and researchers directly affiliated to an academic institution in Ukraine. ...
![PhD student - Mechanisms of cargo recognition by kinesin molecular motors PhD student - Mechanisms of cargo recognition by kinesin molecular motors](/export/sites/btu/.content/images/IL-0021.png_1499001171.png)
PhD student - Mechanisms of cargo recognition by kinesin molecular motors
The Institute of Biotechnology of the Czech Academy of Sciences announces a selection procedure in accordance with the Act No. 283/1992 Coll. on the Czech Academy of Sciences, and the Statutes of the Czech Academy of Sciences for a position
![Research of Protein Network and Its Role in Fertilisation May Help to ... Research of Protein Network and Its Role in Fertilisation May Help to ...](/export/sites/btu/.content/images/bunka.png_1499001171.png)
Research of Protein Network and Its Role in Fertilisation May Help to ...
An important aspect of fertilisation in mammals is the protein network communication between the egg and sperm. These protein complexes undergo crucial changes and rearrangements during sperm movement through the female reproductive tract, where sperm maturation takes place.
![Kateřina Rohlenová received EMBO Installation Grant Kateřina Rohlenová received EMBO Installation Grant](/export/sites/btu/.content/images/DSC-4562.JPG_1499001171.jpg)
Kateřina Rohlenová received EMBO Installation Grant
This year, six group leaders have received EMBO Installation Grants. One of them, and the only recipient in the Czech Republic, is Kateřina Rohlenová from the Institute of Biotechnology AS CR in the BIOCEV centre, who is also a recent holder of a prestigious ERC grant.
![The head of the youngest research group from IBT at the BIOCEV centre has ... The head of the youngest research group from IBT at the BIOCEV centre has ...](/export/sites/btu/.content/images/LOGO_ERC-web.jpg_1499001171.jpg)
The head of the youngest research group from IBT at the BIOCEV centre has ...
Mgr. Katerina Rohlenova, Ph.D. from the Institute of Biotechnology of the Czech Academy of Sciences at the BIOCEV Centre has been awarded the most prestigious European scientific grant by the European Research Council (ERC). She will receive EUR 1.5 million (approximately CZK 38 million) over five years for her innovative research into metabolic communication in tumours.
![COVID-19 testing at BIOCEV for employees only COVID-19 testing at BIOCEV for employees only](/export/sites/btu/.content/images/_MG_7396.jpg_1499001171.jpg)
COVID-19 testing at BIOCEV for employees only
Testing of samples for the presence of SARS-CoV-2 virus by PCR in the BIOCEV centre is available only for employees of the Czech Academy of Sciences and Charles University who work at the Biotechnology and Biomedicine Centre in Vestec. Interested members of the public, companies and other institutions can use testing centres in the vicinity of BIOCEV and Prague.
![The seventh conference Mitochondria, Apoptosis and Cancer 2021 The seventh conference Mitochondria, Apoptosis and Cancer 2021](/export/sites/btu/.content/images/Screenshot-2021-11-22-at-11-56-42-MAC21.png_1499001171.png)
The seventh conference Mitochondria, Apoptosis and Cancer 2021
Dear colleagues, I am taking the liberty of letting you know that on November 25-28, we will organize international biannual conference Mitochondria, Apoptosis and Cancer 2021 (MAC'21) that will be run virtually by our friends from the National University of Singapore. Participation is free of charge and information about the conference is at www.mac21.org. For your information, the inaugural conference, MAC'09, and then MAC'19 were held in Prague. Wish you a pleasant day. prof. Jiri Neuzil
![Zdeněk Lánský received the Czech Science Foundation President’s Award for ... Zdeněk Lánský received the Czech Science Foundation President’s Award for ...](/export/sites/btu/.content/images/Lansky-GACR.jpg_1499001171.jpg)
Zdeněk Lánský received the Czech Science Foundation President’s Award for ...
Excellent scientists have received the Award of the President of the Czech Science Foundation (GACR) for outstanding results in grant projects, which was exceptionally presented this year by GACR Vice President Stanislava Hronová. The prestigious prize for the best basic research was awarded to Zdeněk Lánský (Institute of Biotechnology of the Czech Academy of Sciences)